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Table 2 Updating methods for multinomial logistic regression models with the numbers of parameters that are estimated for updating in general and in the case study

From: Validation and updating of risk models based on multinomial logistic regression

Category

Method and description

Number of parameters

(General = case study)

Original

0—no adjustments

0 = 0

Recalibration

1—intercept recalibration: adjust intercepts

(k − 1) = 2

2—logistic recalibration: adjust intercepts and slopes

k × (k − 1) = 6

 

3—refitting: re-estimation of individual coefficients

(q + 1) × (k − 1) = 8

Revision

4—penalized refitting using recalibrated coefficients from method 2 as offset

(k + q + 1) × (k − 1) = 14

 

5—refitting including functional form: method 3, but hCGr modeled with rcs

(q′ + 1) × (k − 1) = 8

Extension

6—extension: similar to method 3 but log(progesterone) added

(q + m + 1) × (k − 1) = 10

7—penalized extension: similar to method 5 but log(progesterone) added

(k + q + m + 1) × (k − 1) = 16

  1. hCGr human chorionic gonadotropin ratio, rcs restricted cubic spline, k number of outcome categories, q number of variables (including additional nonlinear and interaction terms, but excluding intercepts) in original model, q ′ number of variables when changing functional form of one or more predictors, m number of variables related to added markers