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Table 1 Some examples for the impact of the results of one enrichment design study and/or one interaction study on the time where the test is in use following BBS or VBS, respectively

From: Value-based and benefit-based strategies in deciding to bring a test into use should be distinguished

Test number

Enrichment design study

Interaction design study

Time interval of test use under

 

\({\hat \theta ^{T}_{+}}\)

\({\hat \theta ^{T}_{-}}\)

\({\hat \theta ^{T}_{+}}\)

bbs

vbs

1

0.41 [0.11, 0.51] a

–0.21 [–0.39, –0.03] a

0.57 [0.39, 0.75] a

E- ∞

I- ∞

2

0.54 [0.29, 0.78] a

0.23 [0.01, 0.44] a

0.39 [0.17, 0.52] a

E-I

never

3

0.66 [0.34, 0.99] a

0.11 [–0.21, 0.43]

0.47 [0.13, 0.82] a

E- ∞

never

4

0.29 [0.07, 0.51] a

–

 

E- ∞

never

5

–

–0.32 [–0.57, –0.06] a

0.71 [0.56, 0.95] a

I- ∞

I- ∞

6

–

–0.07 [–0.43, 0.57]

0.53 [0.07, 0.99] a

I- ∞

never

  1. Treatment effects are expressed as log relative risks for treatment success with 95% confidence intervals.
  2. aLog RR significant different from 0 at the 5% level. E and I refer to the time points of the enrichment and the interaction study