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Table 2 List of candidate predictor variables to be evaluated in the PREP study

From: Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study

Maternal characteristics

 Maternal age at diagnosis (years)

 Gestational age at diagnosis (weeks)

 Number of fetuses in pregnancy at time of consent (1, 2, 3)

History

 Summary score for medical history—1 point for each of the following: pre-existing hypertension, renal disease, diabetes mellitus, autoimmune disease, previous history of pre-eclampsia (0, 1, 2 or more)

Symptoms

 Headache and/or visual disturbance (yes/no)

 Epigastric pain, nausea and/or vomiting (yes/no)

 Chest pain and dyspnoea (yes/no)

Bedside examination and tests

 Systolic blood pressure (mmHg, highest measurement over 6 h)

 Diastolic blood pressure (mmHg, highest measurement over 6 h)

 Clonus (yes/no)

 Exaggerated tendon reflexes (yes/no)

 Abnormal oxygen saturation (<95% on air) (yes/no)

 Urine dipstick (0, 1+, 2+, 3+, 4+ or more)

Laboratory tests

 Haemoglobin (g/L)

 Platelet count (× 109/L)

 ALT (IU/L)

 Serum uric acid (μmol/L)

 Serum urea (mmol/L)

 Serum creatinine (μmol/L)

 Urine protein-creatinine ratio (PCR) (mg/mmol)

Management at baseline

 Administration of oral and/or parenteral anti-hypertensives (ongoing or commenced within 1 day of diagnosis) (yes/no)

 Administration of magnesium sulphate (commenced before or within 1 day of diagnosis) (yes/no)

Additional factors for fetal model only

 Uterine artery Doppler (normal/abnormal)

 Liquor volume (normal/abnormal)

 CTG findings (normal/abnormal)

 Estimated fetal weight <10th centile (yes/no)