Table 1 Characteristics of population, predictors and outcome in the IPD meta-analysis on prediction of pre-eclampsia

Predictors

Maternal clinical characteristics at booking: Maternal characteristics: Age, BMI, height, weight, ethnicity, smoking, alcohol or substance misuse; Medical history: pre-existing chronic kidney disease, heritable thrombophilias, autoimmune disease such as systemic lupus erythematosus (SLE) and anti-phospholipid syndrome, type 1 and 2 diabetes and hypertensive diseases; Previous obstetric history: parity, previous pre-eclampsia, GDM, pregnancy interval more than 10 years, family history of pre-eclampsia, family history of cardiovascular disease, previous miscarriages, preterm birth, stillbirth or small for gestational age foetus; Current pregnancy: Multiple pregnancy, mode of conception, early pregnancy bleeding, MAP, systolic and diastolic blood pressure, SES, new partner, diet or exercise in pregnancy, urine dipstick, PCR, 24 h protein

Biochemical markers (first or second trimester): PAPP-A, sflt-1, PlGF, AFP, HCG, soluble endoglin, CRP, Hyper triglyceridaemia and PAI-1

Ultrasound markers (first or second trimester): CRL, AC, expected foetal weight centile, Uterine and umbilical artery Doppler (resistance index, pulsatility index, unilateral or bilateral notching)

Outcomes

Primary outcomes:

Early (<34 weeks), late (≥34 weeks) and any pre-eclampsia

Secondary outcomes:

Maternal complications: Eclampsia, HELLP syndrome, abruption, hepatic and renal failure, cortical blindness, pulmonary oedema, postpartum haemorrhage, DIC, preterm delivery, admission to HDU, maternal death, caesarean section, GDM

Foetal and neonatal complications: Birth weight in Kg and centile, small for gestational age foetus, stillbirth, neonatal death, hypoxic ischemic encephalopathy, respiratory distress syndrome, septicaemia, admission to neonatal unit