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Table 3 Automatically extracted ICPC codes for the index predictors in the CHA2DS2-VASc model and the definition of the reference predictors used for manually scrutinizing the electronic patient file

From: The effects of misclassification in routine healthcare databases on the accuracy of prognostic prediction models: a case study of the CHA2DS2-VASc score in atrial fibrillation

Predictor

ICPC code(s) for index predictors

Definition for reference predictors

Congestive heart failure

K77 heart failure

Signs and symptoms suggestive of heart failure, with structural or functional abnormalities on echocardiography, either with preserved or reduced ejection fraction

Hypertension

K86 hypertension without organ damage

K87 hypertension with organ damage/secondary hypertension

Repeated systolic blood pressure measurement of 140 mmHg or higher

Age

Age in years

Age in years

Diabetes

T90 type 1 and type 2 diabetes

Repeated fasting blood glucose measurement of ≥ 7.0 mmol/L (126 mg/dL) or a non-fasting glucose measurement of ≥ 11.1 mmol/L (200 mg/dL)

Stroke/TIA

K89 TIA

K90 cerebrovascular accident (stroke)

Focal neurological deficit of sudden onset lasting > 24 or < 24 h, respectively

Vascular disease

K74 angina pectoris

K75 acute myocardial infarction

K76 other chronic ischemic heart disease

K91 atherosclerosis

K92 other peripheral arterial disease

K03 other pain suspected to originate from the cardiovascular tract

• Coronary heart disease: prior myocardial infarction (both ST-elevated myocardial infarction or non-ST-elevated myocardial infarction), angina pectoris or prior percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG)

• Peripheral artery disease: symptoms of intermittent claudication with ankle-branchial index ≤ 0.9 or prior surgery or percutaneous intervention on the abdominal or thoracic aorta or lower extremity vessels

Previous thrombo-embolism

Sex category

Female sex

Female sex