Methods for Evaluation of medical prediction Models, Tests And Biomarkers (MEMTAB) 2018 Symposium

Table 1 (abstract O11). Summary of design ranking in different methodological situations

	Stratification design	Two-phase design	Case-control design	Nested case-control design	Comprehensive diagnostic study design	Comparing two tests without verification of double negatives
Methodological situation:
Population
Different strata in patient population	Only option
Index test
Stored data available on index test				Only option
Costly or invasive index test	Second option		Third option	First option
Two index tests	Third option	Second option				First option
Multiple index tests					Only option
Reference standard
Costly or invasive reference standard	Third option	First option				Second option
Target condition
Extremely low prevalence (<0.001%)			Only option
Multiple target conditions					Only option
Risk of Bias QUADAS-2	Higher risk of bias if there is more difference between prevalence strata	Higher risk of bias if the selection of reference standard is not random	Higher risk of bias if cases or controls do not represent the same population	Higher risk of bias if the selection of index test is not random	Higher risk of bias if there is no reference panel to determine the diagnosis	Higher risk of bias if both index tests are not blinded from each other

If there were more than one design applicable, the first three options were ranked on suitability based on sample size and risk of bias. Other designs might be possible as well in specific situations.

ISSN: 2397-7523