Skip to main content

Table 3 Association between potential prognostic factors and outcome (n = 177 pregnancies)

From: First-trimester ultrasound measurements and maternal serum biomarkers as prognostic factors in monochorionic twins: a cohort study

Potential prognostic factor

Unadjusted OR (95%CI)

Adjusted* OR (95%CI)

p value

Change in c-statistic†

Fetal adverse outcome composite

 NT (% discordance)

1.03 (1.01, 1.05)

1.03 (1.01, 1.06)

0.011

0.045

 CRL (% discordance)

1.16 (1.06, 1.27)

1.17 (1.07, 1.29)

0.001

0.103

 AFP

1.91 (0.93, 3.94)

2.08 (0.94, 4.59)

0.071

0.026

 sFlt-1

1.12 (0.52, 2.40)

1.03 (0.42, 2.50)

0.950

< 0.001

 PlGF

0.73 (0.44, 1.22)

0.65 (0.37, 1.13)

0.125

0.014

Twin-twin transfusion syndrome (TTTS)

 NT (% discordance)

1.05 (1.02, 1.08)

1.06 (1.03, 1.10)

< 0.001

0.137

 CRL (% discordance)

1.07 (0.96, 1.20)

1.09 (0.97, 1.23)

0.161

0.032

 AFP

3.04 (1.05, 8.78)

3.24 (1.00, 10.48)

0.050

0.067

 sFlt-1

1.91 (0.62, 5.88)

1.64 (0.44, 6.03)

0.459

0.006

 PlGF

0.43 (0.20, 0.91)

0.42 (0.19, 0.93)

0.032

0.074

Antenatal growth restriction

 NT (% discordance)

1.01 (0.99, 1.03)

1.01 (0.99, 1.04)

0.261

0.014

 CRL (% discordance)

1.17 (1.06, 1.30)

1.20 (1.08, 1.34)

0.001

0.119

 AFP

1.55 (0.67, 3.55)

2.10 (0.82, 5.40)

0.123

0.032

 sFlt-1

1.25 (0.50, 3.13)

1.47 (0.49, 4.35)

0.491

0.011

 PlGF

0.91 (0.50, 1.66)

0.88 (0.44, 1.76)

0.720

−0.001

Single intrauterine fetal death (sIUFD)

 NT (% discordance)

1.01 (0.98, 1.05)

1.02 (0.98, 1.06)

0.425

<−0.001

 CRL (% discordance)

1.17 (1.00, 1.36)

1.19 (1.01, 1.40)

0.035

0.085

 AFP

0.68 (0.16, 2.87)

0.80 (0.17, 3.90)

0.787

−0.004

 sFlt-1

1.27 (0.27, 6.04)

1.79 (0.30, 10.64)

0.523

<−0.001

 PlGF

0.35 (0.13, 0.97)

0.34 (0.12, 0.98)

0.045

0.057

Double intrauterine fetal death (dIUFD)

NT (% discordance)

1.02 (0.98, 1.06)

1.02 (0.98, 1.06)

0.420

−0.005

 CRL (% discordance)

1.06 (0.91, 1.24)

1.12 (0.94, 1.33)

0.221

0.019

 AFP

1.33 (0.34, 5.21)

0.97 (0.18, 5.33)

0.970

<−0.001

 sFlt-1

4.13 (0.92, 18.58)

8.21 (1.02, 66.24)

0.048

0.035

 PlGF

0.23 (0.08, 0.63)

0.18 (0.05, 0.58)

0.005

0.080

  1. The AFP, sFlt-1, and PlGF are loge transformed
  2. *Adjusted for maternal BMI, age, smoking status, ethnicity, parity, and mode of conception. sIUFD and dIUFD were only able to be adjusted for maternal BMI, age, ethnicity, and mode of conception. Italics denote significant associations. P value is related to the adjusted OR
  3. †Change in c-statistic represents the additional prognostic value of each individual potential prognostic factor above the standard prognostic factors (maternal BMI, age, smoking status, ethnicity, parity, and mode of conception). The baseline c-statistics for the fetal adverse outcome composite is 0.594, TTTS is 0.617, antenatal growth restriction is 0.616, sIUFD is 0.625, and dIUFD is 0.783
Back to article page

Diagnostic and Prognostic Research

ISSN: 2397-7523

Contact us