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Table 1 Comparison of summaries and rankings using HR (t,Tfinal), HR (t), AUC C/D(t,t+1), and AUC I/D(t) at time points (a) t=1 year, (b) t=3 years, and (c) t=5 years

From: A comparison of landmark methods and time-dependent ROC methods to evaluate the time-varying performance of prognostic markers for survival outcomes

 

HR(t,Tfinal)

HR(t)

AUC C/D(t,t+1)

AUC I/D(t)

 

\(\widehat {\text {HR}}\)

95% CI

Rank

\(\widehat {\text {HR}}\)

95% CI

Rank

\(\widehat {\text {AUC}}\)

95% CI

Rank

\(\widehat {\text {AUC}}\)

95% CI

Rank

(a) t=1 year

Platelet count

1.28

(1.16, 1.44)

1

1.46

(1.23, 1.75)

4

0.59

(0.53, 0.66)

3

0.59

(0.55, 0.63)

3

Albumin

1.08

(0.97, 1.21)

8

1.25

(1.07, 1.44)

7

0.52

(0.45, 0.57)

8

0.53

(0.49, 0.58)

7

SB2M

1.25

(1.15, 1.40)

3

1.56

(1.32, 1.84)

1

0.64

(0.57, 0.68)

1

0.62

(0.58, 0.66)

1

Calcium

1.15

(1.05, 1.33)

6

1.13

(0.98, 1.32)

8

0.54

(0.48, 0.61)

7

0.51

(0.47, 0.55)

8

Creatinine

1.17

(1.05, 1.32)

5

1.52

(1.33, 1.71)

2

0.58

(0.50, 0.64)

4

0.58

(0.54, 0.62)

5

LDH

1.14

(1.04, 1.26)

7

1.38

(1.22, 1.63)

5

0.56

(0.50, 0.61)

6

0.59

(0.55, 0.63)

4

Age

1.26

(1.15, 1.39)

2

1.31

(1.12, 1.50)

6

0.56

(0.50, 0.63)

5

0.56

(0.50, 0.59)

6

Hemoglobin

1.18

(1.08, 1.31)

4

1.48

(1.32, 1.71)

3

0.60

(0.55, 0.65)

2

0.62

(0.58, 0.65)

2

(b) t=3 years

Platelet count

1.16

(1.01, 1.36)

2

1.46

(1.27, 1.72)

1

0.65

(0.57, 0.72)

1

0.61

(0.57, 0.65)

1

Albumin

1.08

(0.96, 1.31)

6

1.19

(1.05, 1.38)

6

0.54

(0.46, 0.61)

6

0.51

(0.46, 0.55)

7

SB2M

1.11

(0.97, 1.27)

4

1.30

(1.10, 1.49)

2

0.62

(0.53, 0.67)

2

0.58

(0.53, 0.61)

2

Calcium

1.09

(0.97, 1.29)

5

1.19

(1.04, 1.44)

6

0.48

(0.40, 0.57)

8

0.52

(0.50, 0.57)

5

Creatinine

0.97

(0.83, 1.11)

8

1.19

(1.00, 1.33)

6

0.52

(0.44, 0.58)

7

0.48

(0.44, 0.53)

8

LDH

1.14

(1.00, 1.30)

3

1.11

(0.99, 1.25)

8

0.54

(0.46, 0.61)

5

0.52

(0.50, 0.57)

6

Age

1.31

(1.16, 1.49)

1

1.22

(1.08, 1.40)

4

0.57

(0.50, 0.64)

4

0.56

(0.52, 0.59)

4

Hemoglobin

1.06

(0.94, 1.22)

7

1.29

(1.13, 1.47)

3

0.59

(0.51, 0.65)

3

0.57

(0.53, 0.61)

3

(c) t=5 years

Platelet count

1.02

(0.85, 1.20)

4

1.15

(0.99, 1.38)

4

0.45

(0.35, 0.54)

8

0.52

(0.46, 0.54)

4

Albumin

0.98

(0.81, 1.23)

6

1.11

(0.95, 1.38)

5

0.56

(0.46, 0.66)

2

0.50

(0.45, 0.53)

6

SB2M

1.07

(0.91, 1.28)

3

1.08

(0.95, 1.23)

6

0.50

(0.39, 0.60)

4

0.53

(0.48, 0.56)

3

Calcium

1.00

(0.87, 1.40)

5

1.18

(1.05, 1.38)

3

0.61

(0.51, 0.71)

1

0.50

(0.50, 0.57)

6

Creatinine

0.98

(0.78, 1.18)

7

0.97

(0.83, 1.14)

8

0.48

(0.40, 0.57)

7

0.46

(0.42, 0.50)

8

LDH

1.11

(0.89, 1.33)

2

1.21

(1.04, 1.39)

2

0.56

(0.44, 0.64)

3

0.59

(0.53, 0.62)

1

Age

1.33

(1.13, 1.59)

1

1.27

(1.14, 1.47)

1

0.49

(0.41, 0.60)

6

0.57

(0.53, 0.60)

2

Hemoglobin

0.92

(0.77, 1.11)

8

1.07

(0.94, 1.24)

7

0.50

(0.38, 0.62)

5

0.50

(0.46, 0.54)

6