|Reference||Text||Variations in interpretation|
|Rutjes et al. ||
“(…). All patients pass through a single-gate: a single set of criteria for study admission, typically defined by the clinical presentation.”|
“(…) We refer to this as a “two-gate design using healthy controls”. Two different sets of inclusion criteria (gates) are used: one for the diseased and another for the non-diseased participants.”
|A single- and two-gate is defined by the number of eligibility criteria (sets).|
|DAR8||“The majority of included studies comply with a single-gate design, a single sample of individuals with unknown metastatic status was assessed by both the diagnostic test under scrutiny and the reference standard.”||A single-gate study is defined by a single sample with (unknown) disease status and all participants receiving both reference standard and index test.|
“Single-gate: A study design in which only patients with the target condition are recruited.”|
“(…), single-gate studies, that is, studies in which only patients with the target condition (suspected sepsis) were recruited.”
A single-gate study is defined by inclusion of only patients by (known) disease status.|
Later, participants with the target condition are described as suspected individuals.
“Single-gate study: Where a single sample of individuals is assessed by both the index test and reference standard.”|
“Two-gate study: Studies which employ separate sampling schemes for diseased and non-diseased participants, with both groups being assessed by the index test.”
A single-gate is defined by both (a single set of) eligibility criteria and study flow (receiving both tests).|
Two-gate study is defined by (two sets of) eligibility criteria, (known) disease status and study flow both groups receiving the index test.
|DG33||“Single-gate study: Study design where participants’ disease status is unknown and the index test result is evaluated against the reference standard to confirm the diagnosis”||A single-gate is defined by inclusion of participants by only (unknown) disease status and receiving both tests.|