Do we know enough about the effect of low-dose computed tomography screening for lung cancer on survival to act? A systematic review, meta-analysis and network meta-analysis of randomised controlled trials

Table 2 Quality assessment of included studies

Study	Random sequence generation (selection bias)	Allocation concealment (selection bias)	Blinding of participants and personnel (performance bias)	Blinding outcome assessment (detection bias)	Incomplete outcome data (attrition bias)	Selective reporting (reporting bias)	Other risk of bias (power and baseline imbalance)
Direct meta-analysis and network meta-analysis—RCTs of LDCT screening
DANTE [22]	Low	Unclear	Low	Low	Low	Low	Low and low
DLCST [23]	Low	Unclear	Low	Low	Low	Low	Low and low
MILD [24]	Unclear	Unclear	Low	Low	Low	Low	Inadequate and inadequate
NLST [8, 25]	Low	Unclear	Low	Low	Low	Low	Low and low
Network meta-analysis (main)—RCTs of CXR screening
Czech [26, 27]	Low	Unclear	Low	Unclear	Unclear	Low	Unclear and unclear
MAYO [28, 36]	Low	Unclear	Low	Low	Unclear	Low	Unclear and low
Network meta-analysis (sensitivity)—RCTs of CXR screening (post hoc defined high risk sub-group of larger RCT)
PLCO[29]	Low	Unclear	Low	Low	Low	Low	Inadequate and unclear

CXR chest x-ray, LDCT low-dose computed tomography, RCT randomised controlled trial, N not reported, yrs years

ISSN: 2397-7523