Diagnostic and Prognostic Research

Table 2 Quantiles of C-statistic, calibration-in-the-large MAPE_practical and net benefit of the 1000 models, for each sample size

From: Impact of sample size on the stability of risk scores from clinical prediction models: a case study in cardiovascular disease

		Female					Male
	Sample size	2.5%	25%	50%	75%	97.5%	2.5%	25%	50%	75%	97.5%
C-statistic	N_min	0.802	0.852	0.857	0.861	0.864	0.805	0.827	0.831	0.835	0.839
	N_epv10	0.856	0.861	0.863	0.865	0.867	0.826	0.834	0.837	0.839	0.841
	10,000	0.865	0.866	0.867	0.867	0.868	0.840	0.841	0.842	0.843	0.843
	50,000	0.867	0.868	0.868	0.868	0.868	0.843	0.843	0.843	0.843	0.844
	100,000	0.868	0.868	0.868	0.868	0.868	0.843	0.843	0.843	0.844	0.844
Calibration-in-the-large	N_min	−2.22	−1.43	−0.95	−0.47	0.39	−2.56	−1.49	−1.01	−0.45	0.56
	N_epv10	−1.85	−1.27	−0.97	−0.64	−0.11	−2.23	−1.47	−1.02	−0.60	0.29
	10,000	−1.45	−1.13	−0.95	−0.78	−0.44	−1.61	−1.20	−1.01	−0.80	−0.39
	50,000	−1.18	−1.03	−0.95	−0.87	−0.73	−1.28	−1.11	−1.02	−0.93	−0.77
	100,000	−1.11	−1.01	−0.96	−0.90	−0.79	−1.21	−1.08	−1.02	−0.95	−0.85
Mape_practical	N_min	1.13	1.53	1.75	2.00	2.46	1.34	1.79	2.04	2.34	2.91
	N_epv10	0.76	1.03	1.20	1.36	1.74	1.00	1.36	1.57	1.78	2.26
	10,000	0.42	0.55	0.63	0.73	0.90	0.48	0.63	0.73	0.85	1.04
	50,000	0.19	0.25	0.28	0.32	0.40	0.21	0.29	0.33	0.37	0.45
	100,000	0.13	0.17	0.20	0.22	0.28	0.14	0.20	0.23	0.26	0.32
Net benefit	N_min	0.017	0.019	0.020	0.021	0.021	0.024	0.026	0.027	0.028	0.029
	N_epv10	0.020	0.021	0.021	0.021	0.022	0.026	0.027	0.028	0.028	0.029
	10,000	0.021	0.021	0.021	0.022	0.022	0.028	0.028	0.028	0.029	0.029
	50,000	0.021	0.022	0.022	0.022	0.022	0.028	0.029	0.029	0.029	0.029
	100,000	0.021	0.022	0.022	0.022	0.022	0.028	0.029	0.029	0.029	0.029

Performance metrics of the population derived models were as follows. C-statistic: 0.868 (female) and 0.844 (male). Calibration-in-the-large: −0.95% (female) and −1.02% (male). Net benefit: 0.022 (female) and 0.029 (male)

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ISSN: 2397-7523

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