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Table 3 Prognostic factors for training improvement in verbal short-term memory

From: Prognostic factors for change in memory test performance after memory training in healthy older adults: a systematic review and outline of statistical challenges

StudyTest for outcome assessmentDependent variablePrognostic factor
Multiple regression
   AgeEducationSexNeuropsychologyImagingOthers
de Lange et al., [32]Word listStandardized residuals    White matter microstructure → 
McDougall et al. [40]HVLT
RBMT
Relative gains  Pre-test score ↑ Ethnicity →
Neely and Bäckman [42]Immediate recall of word listPost-test scores MMSE ↑
Pre-test score ↑ *
  
Rosi et al. [44]Immediate recall of word listPost-test scores  Pre-test ↑*
Working memory ↓
Fluid ability ↓
Crystallized ability ↑*
Processing speed ↑
Short-term memory ↓
  
Sandberg et al. [45]Number recallPost-test scores↓*  Episodic memory ↑*
Processing speed ↓
Working memory ↑*
Verbal knowledge ↑
  
Brooks et al. [8]Name recallPost-test scores↑*  Pre-test score* Pretraining x mnemonic training →
Correlation analysis
Mohs et al. [21]HVLTPost-test scores  Subjective reported memory →
Kirchhoff, Anderson, Smith, Barch et al., [22]Recognition memory decisionsChange score    Activity in frontal cortex ↑ 
Kirchhoff, Anderson, Smith et al., [22]Recognition memory decisionsChange score    Activity in hippocampus ↑ 
Andrewes et al. [26]Face-name testChange score   NART →
RAVT →
Warrington Forced Choice Recognition ↑
 Depression →
Mattis dementia scale →
Bråthen et al. [29]Immediate recall of word listn.a.    Hippocampal volume ↑*
Amplitude of low frequency fluctuation ↓
Fractional amplitude of low frequency fluctuation ↓*
 
Finkel and Yesavage [35]Immediate recall of word listGain scoresxx MMSE x Openness of experience ↑*
Depression x
Extraversion x
Neuroticism x
Hill et al. [37]Face-name recallStandardized residual scores     Rated confidence ↑
Hill et al. [38]Face-name recallPerformance changes   MMSE ↑  
Group comparisons (ANOVA, t test)
Clark, Xu, Callahan et al., [30]HVLT
RAVL
RBMT
Relative mean improvement     Obesity ↓*
Clark, Xu, Unverzagtet al., [31]HVLT
RAVL
RBMT
Relative mean improvement     
McDougall et al. [40]HVLT
RBMT
n.a.    Ethnicity (Blacks and Hispanics scored lower than Whites)
Mixed models
Tomaszewski Farias et al. [34]HVLT
RAVL
RBMT
Normalized residuals     Activities of daily living ↑
López-Higes et al. [39]Word list recall
Logical memory test
n.a.     Apolipoprotein E4 →
No clear reporting
Bissig and Lustig [28]Rank-testn.a.  Crystallized intelligence ↑  
de Lange et al., [33]Word listStandardized residuals    White matter microstructure ↑ 
  1. Studies are sorted according to the statistical method used for obtaining the prognostic factors
  2. HVLT Hopkins Verbal learning Task, MMSE Mini Mental State Examination, NART National Adult Reading Test, RAVL Rey Auditory Verbal Learning Test, RBMT Rivermead Behavioral Memory Test, ↑ the higher the prognostic factor, the higher the improvement/positive correlation, ↓ the lower the prognostic factor, the higher the improvement/negative correlation, → no direction of effect reported, * significant, x unclear reporting
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