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Table 2 Guidance for completion of the primary diagnosis framework

From: Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study

Framework diagnosis

Clinical information may include

Investigations

Secondary prevention planned

Definite stroke/TIA

Symptoms typical for a vascular territory.

Time course typical of stroke or TIA.

Vascular risk factors are present.

Imaging supports the clinical diagnosis with no suggestion of an alternative aetiology.

Full (as appropriate)

Probable stroke/TIA

Symptoms mostly typical of a vascular territory.

Time course suggestive of stroke or TIA.

No vascular risk factors or a less common cause of stroke or TIA.

Imaging supports the clinical diagnosis with no suggestion of an alternative aetiology.

No mimic diagnosis suggested by other investigations

Full (as appropriate)

Definite mimic

Positive clinical evidence from history/examination and/or previous medical history consistent with a mimic condition

Evidence consistent with a mimic diagnosis on CT/MRI imaging or other investigations.

No new secondary prevention.

Probable mimic

Symptoms more suggestive of a mimic than a vascular territory.

Vascular risk factors may be present.

No relevant PMH of a mimic condition

No CT or MRI evidence of new stroke but no alternative imaging diagnosis.

No mimic diagnosis suggested by other investigations.

No new secondary prevention.

Unclear

Symptoms not typical of a vascular territory and/or time course not typical of stroke or TIA.

No reason for stroke or TIA to occur.

No positive clinical evidence from history/examination or previous medical history consistent with a mimic condition

No CT or MRI evidence of new stroke but no alternative imaging diagnosis.

No mimic diagnosis suggested by other investigations.

Simple or no new secondary prevention considered appropriate.