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Table 2 Pooled estimates of the regression coefficients \( \hat{\beta_k,} \) ORs and the 95% CrIs for each one of the parameters in the model (centralized to the mean), using Rubin’s rules. The estimated σ (standard deviation of the impact of the variables on multiple observations for the same individuals) is 0.01. The estimated correlation ρ between the effects of the variables is 0.49. The pooled optimism-corrected AUC is 0.65 and the pooled optimism-corrected calibration slope is 0.91. Disease duration was transformed to log(disease duration+10), and months since last relapse was transformed to log(months since last relapse+10)

From: Development, validation and clinical usefulness of a prognostic model for relapse in relapsing-remitting multiple sclerosis

Parameters

\( \hat{\beta_k} \)

OR

95% CrI

Age

-0.035

0.97

(0.95, 0.98)

Disease duration

0.337

1.40

(0.90, 2.18)

EDSS

0.122

1.13

(1.02, 1.25)

Number of gadolinium-enhanced lesions (> 0 vs 0)

− 0.034

0.97

(0.69, 1.36)

Number of previous relapses (1 vs 0)

− 0.070

0.93

(0.69, 1.26)

Number of previous relapses (2 or more vs 0)

0.133

1.14

(0.81, 1.61)

Months since last relapse

− 0.478

0.62

(0.49, 0.78)

Treatment naïve (yes vs no)

0.086

1.09

(0.80, 1.49)

Gender (female vs male)

0.254

1.29

(0.97, 1.72)

On treatment (yes vs no)

− 0.221

0.80

(0.50, 1.27)