The comparative interrupted time series design for assessment of diagnostic impact: methodological considerations and an example using point-of-care C-reactive protein testing

Table 2 Estimated mean and standard deviation of 12-month forecasted number of prescriptions calculated without (columns 2 and 3) and with (columns 4 and 5) allowance for correlation in forecasted values

	Directly calculated		Simulated (allowing for correlation)
Base	\( {\hat{m}}_{12} \)	\( {\hat{s}}_{12} \)	\( {\hat{m}}_{12} \)	\( {\hat{s}}_{12} \)
Stoke Mandeville	1618	97	1615	98
Clacton	1485	82	1484	82
Bury St Edmunds	1505	99	1505	116
Nuneaton	1283	111	1281	135
Warwick	1114	84	1112	130
Kidderminster	1106	99	1107	117
Redditch	1645	133	1642	226
Worcestershire Royal	1605	93	1606	92

ISSN: 2397-7523