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Table 3 Diagnostic accuracy of a series of composite reference standards for each form of extrapulmonary TB

From: Bayesian latent class analysis produced diagnostic accuracy estimates that were more interpretable than composite reference standards for extrapulmonary tuberculosis tests

 

CRS 1+

CRS 2+

CRS 3+

CRS4+

TB lymphadenitis

Sensitivity (%) (95% CI)

99.8 (97.0, 100)

97.1 (89.1, 99.5)

81.8 (74.8, 84.2)

26.4 (24.2, 27.2)

Specificity (%) (95% CI)

83.9 (80.9, 92.3)

99.6 (98.4, 100)

100 (100, 100)

100 (100, 100)

  

TB meningitis

  

Sensitivity (%) (95% CI)

95.0 (84.6, 99.6)

64.4 (46.3, 87.1)

44.4 (31.3, 61.9)

17.8 (12.5, 24.8)

Specificity (%) (95% CI)

88.3 (84.8, 94.1)

98.8 (97.8, 99.9)

100 (100, 100)

100 (100, 100)

  

TB pleuritis

  

Sensitivity (%) (95% CI)

98.9 (96.0, 99.9)

75.5 (56.3, 94.8)

31.1 (23.1, 39.2)

9.00 (6.70, 11.4)

Specificity (%) (95% CI)

73.7 (67.2, 88.0)

99.3 (97.9, 100)

100 (99.8, 100)

100 (100, 100)

  1. CRS 1+ indicates any one positive test in CRS versus all four parameters being negative. CRS 2+: any two tests positive in CRS versus all four parameters being negative. CRS 3+: any three tests positive in CRS versus all four parameters being negative. CRS 4+: all four tests positive in CRS versus all four parameters being negative [17]. Lymph node samples were used for TB lymphadenitis; CSF samples were used for TB meningitis; pleural fluid samples were used for TB pleuritis
  2. CI confidence interval, CRS composite reference standard, CSF cerebral spinal fluid, TB tuberculosis