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Table 6 Observed counts, expected counts, and TB pleuritis probability by test result pattern

From: Bayesian latent class analysis produced diagnostic accuracy estimates that were more interpretable than composite reference standards for extrapulmonary tuberculosis tests

Culture

Xpert

Smear

ADA

No. observed

No. expected by LCA (95% CrI)

Probability of TB pleuritis by LCA (95% CrI)

Probability of TB pleuritis by CRS

CRS1+

CRS2+

CRS3+

CRS4+

180

175 (162, 185)

0.008 (0, 0.03)

0

0

0

0

+

84

86 (75, 98)

0.33 (0.06, 0.78)

1

0

0

0

+

1

1 (0, 4)

0.005 (0, 0.07)

1

0

0

0

+

4

6 (2, 11)

0.016 (0, 0.10)

1

0

0

0

+

+

4

4 (2, 7)

0.54 (0.05, 0.92)

1

1

0

0

+

1

4 (1, 7)

0.70 (0.2, 0.99)

1

0

0

0

+

+

50

45 (36, 53)

0.99 (0.96, 1)

1

1

0

0

+

+

+

3

3 (1, 6)

1.0 (0.99, 1)

1

1

1

0

+

+

2

1 (0, 3)

0.98 (0.81, 0.99)

1

1

0

0

+

+

+

24

26 (20, 33)

1.0 (0.99, 1)

1

1

1

0

+

+

+

+

11

12 (8, 16)

1.0 (0.99, 1)

1

1

1

1

NA

3

NE

0.02 (0.01, 0.05)

NE

0

1

0

NA

+

7

NE

0.53 (0.33, 0.84)

1

NE

0

0

NA

+

1

NE

0.29 (0.10, 0.62)

1

NE

0

0

NA

+

+

6

NE

0.98 (0.96, 1)

1

1

NE

0

NA

+

+

1

NE

0.59 (0.28, 0.93)

1

1

NE

0

NA

+

+

+

4

NE

0.99 (0.98, 1)

1

1

1

NE

NA

+

+

NA

1

NE

0.99 (0.96, 1)

1

1

NE

NE

NA

NA

NA

1

NE

0.32 (0.23, 0.45)

NE

NE

NE

0

  1. Tests were all performed in pleural fluid samples (n = 388). A “+” indicates positive test result and “−” indicates negative test result. CRS 1+ indicates any one positive test in CRS versus all four parameters being negative. CRS 2+: any two tests positive in CRS versus all four parameters being negative. CRS 3+: any three tests positive in CRS versus all four parameters being negative. CRS 4+: all four tests positive in CRS versus all four parameters being negative
  2. ADA adenosine deaminase, CrI credible interval, LCA latent class analysis, NA value not available, NE result not estimable. No. number of, Smear smear microscopy, TB tuberculosis