Fig. 1

Flowchart of planned analyses: Typhoid review. Different components of variation leading to complexity in review of typhoid rapid tests. Coloured boxes indicate the TOMAS-R domain where complexity identified: pink boxes review topic; light blue boxes participant domain; dark blue boxes index test domain; light green boxes target condition domain; dark green boxes study design and quality domain. Dotted lines separate complexity and allow alignment to the diagnostic accuracy that the analysis would address. Each bullet point follows the question “What is the diagnostic accuracy...” so for example if all rapid test results are combined the first bullet point is used so the analysis will answer the question “What is the diagnostic accuracy averaged over all tests and test thresholds?” Yellow stars indicate key complexities identified as requiring separate analyses for the review to have clinical relevance