Fig. 2

Flowchart of planned analyses: Ovarian cancer serum biomarker review. Different components of variation leading to complexity in review of serum biomarkers in ovarian cancer. Coloured boxes indicate the TOMAS-R domain where complexity identified: pink boxes review topic; light blue boxes participant domain; dark blue boxes index test domain; light green boxes target condition domain. Dotted lines separate complexity and allow alignment to the diagnostic accuracy that the analysis would address. Each bullet point follows the question “What is the diagnostic accuracy...” so for example if test results are separated by the menopausal status of the women, the second bullet point is used so the analysis will answer the question “What is the diagnostic accuracy averaged separately for each menopausal group?” Yellow stars indicate key complexities identified as requiring separate analyses for the review to have clinical relevance