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Table 1 Model parameters and data sources

From: Cost implications for the NHS of using the Alere™ i Influenza A & B near patient test with nasal swabs

Parameter for the model Base case value Data source
Number of participants in study 1000  
Sensitivity of NPT with nasal swabs 0.98 Bell et al. [9]
Specificity of NPT with nasal swabs 0.86 Bell et al. [9]
Sensitivity of NPT with throat swabs 0.76 Davis et al. [4]
Specificity of NPT with throat swabs 0.97 Davis et al. [4]
Prevalence of influenza 0.17 Bell et al. [9]
Length of stay, influenza diagnosed (days) 5.00 Duration of antiviral treatment
Length of stay, influenza not diagnosed (days) 3.00 Av days to PCR result
Cost of NPT test 23.45 Estimate
Cost of RT-PCR 70.00 Estimate
Cost of full isolation
(Cost of partial isolation = cIsol/2)
88.43 Health Protection Scotland [14]
Cost per dose of 75 mg oseltamivir (taken every 12 h) 1.54 MIMS [15]
Cost of nosocomial infection 2*(cOseltamivir * 2 * RxOseltamivir + cIsol*los) NICE guidance [1]
Number of days for oseltamivir treatment 5.00 MIMS [15]
Probability of isolation if influenza detected 1.00 Expert opinion
Probability of isolation if influenza not detected 0.00 Expert opinion
Probability of nosocomial infection 0.20 Expert opinion