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Table 1 Key input parameters of the model

From: Lung cancer screening by low-dose computed tomography: a cost-effectiveness analysis of alternative programmes in the UK using a newly developed natural history-based economic model

Description Base case value Source
Number of smokers aged 55–80 13,000,000 Office of National Statistics [36] Health survey for England [27]
Probability someone responds to the initial invite and returns the questionnaire 0.307 UKLS trial [6]
Probability someone joins screening programme given they are eligible 0.465 UKLS trial [6]
Sensitivity of low-dose CT test for lung cancer 0.709 UKLS trial [6]
Specificity of low-dose CT test for lung cancer 0.624 UKLS trial [6]
Utility of male smoker in the UK general population/occult lung cancer 0.7816 Health Survey for England [27]
Utility of female smoker in the UK general population/occult lung cancer 0.7531 Health Survey for England [27]
Disutility associated with a false-positive screen − 0.063 Mazzone et al. [30]
Disutility associated with anxiety of a screening event − 0.010 NELSON trial [29]
Duration of disutility from false-positive screen 3 months Assumption
Duration of disutility from screening anxiety 2 weeks Assumption
Cost of low-dose CT scan £98.80 NHS Reference costs 2015/2016 [31]