Table 1 Overview of the inclusion and exclusion criteria of PROVALID, GCKD, and DIACORE

PROVALID

▪ Aged 18–75 years

▪ Incident or prevalent DM2 with/without CKD

• Active malignancy requiring chemotherapy

GCKD

▪ Aged 18–74 years

▪ Caucasian ethnicity

▪ eGFR: 30–60 mL/min/1.73m²with or without urinary albumin excretion

▪ eGFR > 60 mL/min/1.73m²

- Albumin excretion of > 300mg/g creatinine

- Proteinuria > 500mg/day

▪ Active malignancy in the 24 months prior to inclusion

▪ Renal or other transplantations

▪ NYHA IV heart failure

DIACORE

▪ Aged ≥ 18 years

▪ Caucasian ethnicity

▪ Prevalent DM2

▪ On chronic renal replacement therapy

▪ Active malignancy

▪ Pregnancy

▪ Further diseases and infections