Table 1 Proposed candidate predictors
Candidate predictors identified from QRISK-3 relevant to women [4] | Candidate predictors identified from Umbrella Review [26] | Candidate predictors identified from discussions within the research team |
|---|---|---|
Patient characteristics • Age • Ethnicity • Deprivation • Systolic blood pressure (SBP) • Body mass index (BMI) • Total cholesterol: high-density lipoprotein cholesterol ratio • Smoking status Medical history predictors • Family history of coronary heart disease • Diabetes mellitus • Treated hypertension • Rheumatoid arthritis • Atrial fibrillation • Chronic kidney disease (stages 4 or 5) • Expanded definition of chronic kidney disease (to include general practitioner recorded diagnosis of chronic kidney disease stage 3 in addition to stages 4 and 5 as well as major chronic renal disease) • The standard deviation of SBP (variability of repeated SBP measures) • Diagnosis of migraine • Corticosteroid use • Systemic lupus erythematosus • Second generation “atypical” antipsychotic use • Diagnosis of severe mental illness | Reproductive health factors • Early age at menarche (<12 years old) • Use of hormonal contraceptive agents • Use of oral contraceptives • Polycystic ovary syndrome • Parity/gravidity Adverse pregnancy outcomes • Hypertensive disorders of pregnancy • Gestational diabetes mellitus • Placental abruption • Pregnancy loss • Preterm birth • Low birth weight and small for gestational age | • Idiopathic intracranial hypertension • Postnatal depression • Hypothyroidism • Hyperthyroidism • Endometriosis • Menstrual irregularity • Antiphospholipid syndrome |