Table 7 Predictor prevalence in NRCBM and the non-overlapping replication datasets
Predictor | NRCBM case % | NRCBM control % | Replication case % | Replication control % | Case difference | Control difference |
|---|---|---|---|---|---|---|
Anxiety | 4.99 | 1.10 | 9.24 | 0.76 | 4.25 | − 0.34 |
Asthma | 15.87 | 10.66 | 8.37 | 3.42 | − 7.50 | − 7.24 |
Back pain with specific characteristics | 1.38 | 0.65 | 1.07 | 0.30 | − 0.31 | − 0.35 |
Back pain without specific characteristics | 11.00 | 5.75 | 8.37 | 2.86 | − 2.64 | − 2.89 |
Bed wetting | 0.12 | 0.07 | 0.09 | 0.08 | − 0.03 | 0.01 |
Bereavement | 1.19 | 0.30 | 0.91 | 0.17 | − 0.28 | − 0.14 |
Developmental delay | 2.29 | 1.92 | 2.77 | 2.24 | 0.49 | 0.32 |
Diabetes | 0.13 | 0.61 | 0.60 | 0.74 | 0.47 | 0.12 |
Dysmenorrhea | 3.11 | 2.02 | 2.07 | 0.95 | − 1.04 | − 1.07 |
Dyspepsia | 12.16 | 5.37 | 9.94 | 3.01 | − 2.22 | − 2.36 |
Eating disorders | 0.92 | 0.25 | 1.01 | 0.12 | 0.09 | − 0.13 |
Emotion | 0.06 | 0.02 | 0.06 | 0.03 | 0.00 | 0.01 |
Epilepsy | 1.25 | 0.83 | 1.33 | 0.34 | 0.07 | − 0.50 |
Headache | 12.16 | 5.37 | 12.7 | 3.79 | 0.54 | − 1.58 |
Homeless | 0.08 | 0.03 | 0.07 | 0.00 | − 0.01 | − 0.03 |
Alcohol misuse | 0.76 | 0.31 | 1.15 | 0.25 | 0.38 | − 0.06 |
Drug misuse | 1.01 | 0.29 | 0.72 | 0.09 | − 0.29 | − 0.20 |
Loss of enjoyment | 0.13 | 0.05 | 1.19 | 0.01 | 1.05 | − 0.04 |
Low mood | 5.90 | 0.84 | 25.73 | 0.77 | 19.83 | − 0.07 |
Missed immunization | 0.67 | 0.57 | 2.26 | 1.85 | 1.59 | 1.28 |
Neonatal | 8.77 | 7.62 | 10.38 | 8.46 | 1.61 | 0.84 |
Non-accidental injuries | 1.86 | 0.73 | 1.19 | 0.45 | − 0.66 | − 0.28 |
OCD | 0.44 | 0.07 | 0.56 | 0.04 | 0.11 | -0.03 |
Social Services Involvement | 0.08 | 0.06 | 0.20 | 0.14 | 0.12 | 0.08 |
Police involvement | 0.05 | 0.02 | 0.05 | 0.01 | 0.00 | − 0.01 |
Psychosexual problems | 0.30 | 0.11 | 0.31 | 0.06 | 0.01 | − 0.05 |
PTSD | 0.19 | 0.04 | 0.34 | 0.01 | 0.15 | − 0.03 |
School problems | 0.34 | 0.10 | 0.24 | 0.06 | − 0.10 | − 0.04 |
Self-harm | 1.50 | 0.29 | 2.35 | 0.26 | 0.85 | − 0.03 |
Skin disorders | 14.49 | 11.8 | 12.8 | 7.84 | − 1.69 | − 3.96 |
Sleep disorder, too little | 0.90 | 0.22 | 1.20 | 0.09 | 0.31 | − 0.13 |
Sleep disorder, too much | 0.03 | 0.01 | 0.30 | 0.01 | 0.27 | 0.00 |
Teenage pregnancy | 0.02 | 0.01 | 0.00 | 0.00 | − 0.01 | − 0.01 |
Tiredness | 2.94 | 1.16 | 1.19 | 0.37 | − 1.76 | − 0.80 |
Unemployment | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 |
Other somatic symptoms | 0.11 | 0.03 | 0.10 | 0.01 | − 0.01 | − 0.02 |
Ill-defined conditions | 0.51 | 0.28 | 0.23 | 0.11 | − 0.27 | 0.17 |
Weight gain | 0.18 | 0.10 | 0.08 | 0.03 | − 0.10 | − 0.07 |
Weight loss | 0.90 | 0.35 | 0.59 | 0.13 | − 0.30 | − 0.23 |
Work stress | 0.08 | 0.02 | 0.06 | 0.01 | − 0.02 | − 0.01 |
Carer | 0.08 | 0.06 | 0.23 | 0.07 | 0.15 | 0.01 |
Smoker | 38.12 | 24.2 | 23.9 | 7.04 | − 14.22 | − 17.17 |
Missing (smoker data) | 15.29 | 22.93 | 12.39 | 26.40 | − 2.90 | 3.47 |
Divorce | 0.01 | 0.00 | 0.00 | 0.00 | − 0.01 | 0.00 |
Abdominal pain | 7.61 | 3.7 | 4.92 | 1.64 | − 2.69 | − 2.07 |
Excessive sweating | 0.59 | 0.37 | 0.58 | 0.23 | − 0.01 | − 0.14 |
Puberty, early or late | 0.23 | 0.19 | 0.34 | 0.26 | 0.11 | 0.06 |
Family history of depression | 0.00 | 0.00 | 0.04 | 0.00 | 0.04 | 0.00 |
Family history of drug abuse | 0.01 | 0.00 | 0.00 | 0.00 | − 0.01 | 0.00 |
Family history of alcohol abuse | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
Family History of abuse | 0.01 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 |